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KMID : 0613819990090030300
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Journal of Life Science
1999 Volume.9 No. 3 p.300 ~ p.307
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The Effect of Tocopherol and Ascorbate on the Enzyme Activity and Antioxidation in CCl4 Induced Rats
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Abstract
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The enzyme activities and antioxidative of tocopherol and ascorbate were investigated at the levels of liver, kidney homogenates and sera of SD-rats intoxicated with tetrachlorocarbon(CCl4). GOT and GPT activities of sera in the CCl4 group were 3, 6 times increased compared to normal group. But they tended to decrease significantly in tocopherol and ascorbate administered group. As for BUN and total cholesterol they were the same. HDL-cholesterol in the CCl4 group was 42% decreased compared to normal group. HDL-cholesterol was about 26% increased in the tocopherol group and tocopherol ascorbate group compared to CCl4 group. MDA and SOD activities in the liver and the kidney tissue homogenates were significantly increased in CCl4 group compared to normal group. But they were decreased significantly in the tocopherol group and tocopherol-ascorbate group compared to CCl4 group. In view of this study tocopherol and ascorbated were ascorbate were effective on the detoxication of liver and kidney injury.
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